1. Basic Concepts of Repeated Measures: In this basic setup of a completely randomized design with repeated measures, there are two factors, treatments and time. Treatment is called the between-subjects factor because levels of treatment can change only between subjects; all measurements on the same subject will represent the same treatment. Time is called a within-subjects factor because different measurements on the same subject are taken at different times. In repeated measures experiments, interest centers on (1) how treatment means differ, (2) how treatment means change over time, and (3) how differences between treatment means change over time. 2. Four-step procedure for mixed model analysis: Step 1: Model the mean structure, usually by specification of the fixed effects. Step 2: Specify the covariance structure, between subjects as well as within subjects. Step 3: Fit the mean model accounting for the covariance structure. Step 4: Make statistical inference bas...
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