Background: Melanoma Also called: malignant melanoma The most serious type of skin cancer. Melanoma occurs when the pigment-producing cells that give color to the skin become cancerous. Symptoms might include a new, unusual growth or a change in an existing mole. Melanomas can occur anywhere on the body. Treatment may involve surgery, radiation, medications, or in some cases chemotherapy. Merkel cell carcinoma (MCC) it is a very rare , highly aggressive, neuroendocrine carcinoma of the skin ; it has a worse survival probability compared with more common cutaneous malignancies, including metastatic melanoma, and has been termed the “most lethal” skin cancer as p atients with metastatic MCC have a historical 5-year overall survival (OS) rate of 18% What Is Tumor Mutational Burden? TMB is defined as the frequency of certain mutations within a tumor’s genes. To be counted towards TMB, mutations have to alter the protein that is made from a gene. ...
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