In clinical trials and survival analyses, statements like: “ The median DoR was not estimable with a median duration of follow-up of 26.6 months ,” or “ The median PFS and OS were not estimable ” typically mean that insufficient events (e.g., disease progression, death, or end of response) have occurred at the time of data cutoff to accurately estimate the median using Kaplan-Meier survival analysis . Here’s a breakdown of the reasoning: 🔍 What Does "Not Estimable" Mean? In the context of Kaplan-Meier curves , median is the time at which 50% of patients have experienced the event (e.g., progression, death, end of response). If fewer than 50% of patients have had the event by the data cutoff, then the median cannot be computed because the curve hasn’t dropped to 50%. So the median is “not estimable” (NE) or not reached . 📌 Common Scenarios for NE (Not Estimable): Durable responses or long survival : If a large proportion of patients are st...
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